USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.
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ABSTRACT:
SUBMITTER: Zhu M
PROVIDER: S-EPMC8490862 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Publications
USP52 inhibits cell proliferation by stabilizing PTEN protein in non-small cell lung cancer.
Zhu Maoshu M Zhang Hui H Lu Fuhua F Wang Zhaowei Z Wu Yulong Y Chen Huoshu H Fan Xin X Yin Zhijiang Z Liang Fulong F
Bioscience reports 20211001 10
Non-small cell lung cancer (NSCLC) is the most common subtype of lung cancer. Ubiquitination is closely related to the development of lung cancer. However, the biological importance of newly discovered ubiquitin-specific peptidase (USP) 52 (USP52) in NSCLC remained unclear. Here, our findings identify USP52 as a novel tumor suppressor of NSCLC, the low expression of USP52 predicts a poor prognosis for NSCLC patients. The present study demonstrates that USP52 inhibits cancer cell proliferation th ...[more]
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