Neostigmine for Treating Acute Colonic Pseudo-Obstruction in Neurocritically Ill Patients.

ABSTRACT:

Background and purpose

Acute colonic pseudo-obstruction (ACPO) is a common but understudied complication in neurocritically ill patients. The acetylcholinesterase inhibitor neostigmine can be used to treat ACPO in patients who do not respond to conventional treatment. This study investigated the effectiveness and adverse events when using neostigmine to manage ACPO in neurocritically ill patients.

Methods

This retrospective study investigated patients with ACPO who were treated using neostigmine in the neurological intensive-care units at two centers between March 2017 and August 2020. Neostigmine was administered intravenously or subcutaneously (at doses ranging from 0.25 mg to 2 mg) according to the protocols at the two centers. The outcomes were bowel movements and the ch

SUBMITTER: Kim TJ 

PROVIDER: S-EPMC8490912 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature