Decoding Partner Specificity of Opioid Receptor Family.

ABSTRACT: This paper describes an exciting big data analysis compiled in a freely available database, which can be applied to characterize the coupling of different G-Protein coupled receptors (GPCRs) families with their intracellular partners. Opioid receptor (OR) family was used as case study in order to gain further insights into the physiological properties of these important drug targets, known to be associated with the opioid crisis, a huge socio-economic issue directly related to drug abuse. An extensive characterization of all members of the ORs family (μ (MOR), δ (DOR), κ (KOR), nociceptin (NOP)) and their corresponding binding partners (ARRs: Arr2, Arr3; G-protein: G_i1, G_i2, G_i3, G_o, G_ob, G_z, G_q

SUBMITTER: Barreto CAV 

PROVIDER: S-EPMC8490921 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature