Cell type-specific transcriptomics identifies neddylation as a novel therapeutic target in multiple sclerosis.

ABSTRACT: Multiple sclerosis is an autoimmune disease of the CNS in which both genetic and environmental factors are involved. Genome-wide association studies revealed more than 200 risk loci, most of which harbour genes primarily expressed in immune cells. However, whether genetic differences are translated into cell-specific gene expression profiles and to what extent these are altered in patients with multiple sclerosis are still open questions in the field. To assess cell type-specific gene expression in a large cohort of patients with multiple sclerosis, we sequenced the whole transcriptome of fluorescence-activated cell sorted T cells (CD4+ and CD8+) and CD14+ monocytes from treatment-naive patients with multiple sclerosis (n = 106) and healthy subjects (n = 22). We identified 479 differential

SUBMITTER: Kim K 

PROVIDER: S-EPMC8491073 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature