Ontology highlight
ABSTRACT:
SUBMITTER: Zhang Y
PROVIDER: S-EPMC8491194 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Zhang Yibo Y Ouyang Man M Wang Hailong H Zhang Bihui B Guang Wenhua W Liu Ruiwu R Li Xiaocen X Shih Tsung-Chieh TC Li Zhixin Z Cao Jieqiong J Meng Qiling Q Su Zijian Z Ye Jinshao J Liu Feng F Hong An A Chen Xiaojia X
MedComm 20201214 3
In malignancies, fibroblast growth factor receptors (FGFRs) signaling is reinforced through overexpression of fibroblast growth factors (FGFs) or their receptors. FGFR2 has been proposed as a target for cancer therapy, because both the expression and activation of FGFR2 are boosted in various malignant carcinomas. Although several chemicals have been designed against FGFR2, they did not exhibit enough specificity and might bring potential accumulated toxicity. In this study, we developed an epit ...[more]