A polymorphism in the promoter of FRAS1 is a candidate SNP associated with metastatic prostate cancer.

ABSTRACT:

Background

Inflammation and one of its mediators, NF-kappa B (NFκB), have been implicated in prostate cancer carcinogenesis. We assessed whether germline polymorphisms associated with NFκB are associated with the risk of developing lethal disease (metastases or death from prostate cancer).

Methods

Using a Bayesian approach leveraging NFκB biology with integration of publicly available datasets we used a previously defined genome-wide functional association network specific to NFκB and lethal prostate cancer. A dense-module-searching method identified modules enriched with significant genes from a genome-wide association study (GWAS) study in a discovery data set, Physicians' Health Study and Health Professionals Follow-up Study (PHS/HPFS). The top 48 candidate single nucleot

SUBMITTER: Wang V 

PROVIDER: S-EPMC8491321 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature