Molecular correlates of MRS-based ³¹ phosphocreatine muscle resynthesis rate in healthy adults.

ABSTRACT: Dynamic phosphorus MRS (³¹ P-MRS) is a method used for in vivo studies of skeletal muscle energetics including measurements of phosphocreatine (PCr) resynthesis rate during recovery of submaximal exercise. However, the molecular events associated with the PCr resynthesis rate are still under debate. We assessed vastus lateralis PCr resynthesis rate from ³¹ P-MRS spectra collected from healthy adults as part of the CALERIE II study (caloric restriction), and assessed associations between PCr resynthesis and muscle mitochondrial signature transcripts and proteins (NAMPT, NQO1, PGC-1α, and SIRT1). Regression analysis indicated that higher concentration of nicotinamide phosphoribosyltransferase (NAMPT) protein, a mitochondrial capacity marker, was associated with faster P

SUBMITTER: Darpolor MM 

PROVIDER: S-EPMC8491428 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature