Carboxypeptidase B2 and N play different roles in regulation of activated complements C3a and C5a in mice.

ABSTRACT: Essentials Two basic carboxypeptidases are present in plasma, B2 (CPB2) and N (CPN). Cpb2^-/- and Cpn^-/- mice were challenged in a hemolytic uremic syndrome (HUS) model vs. wild type. Cpb2^-/- exacerbates HUS while Cpn^-/- exacerbates cobra venom factor challenge vs. wild type mice. CPB2 and CPN have overlapping but non-redundant roles.

Summary

Background There are two basic carboxypeptidases in plasma. Carboxypeptidase B2 (CPB2) is activated from a circulating zymogen, proCPB2, and carboxypeptidase N (CPN) is constitutively active with both inactivating complement C3a and C5a. Aims To test the roles of CPB2 and CPN in complement-driven mouse models of cobra venom factor (CVF) challenge and hemolytic-uremic syndrome (HUS). Methods Cpb2^-/

SUBMITTER: Morser J 

PROVIDER: S-EPMC8491566 | biostudies-literature | 2018 May

REPOSITORIES: biostudies-literature