Polymorphic variants in genes related to stress coping are associated with the awake bruxism.

ABSTRACT:

Background

Chronic stress is one of the leading predisposing factors in bruxism aetiology, but the influence of genetic factors is also suggested. We aimed to study whether sequence variants in genes involved in stress regulation pathways: NTRK2 and BDNF, may be associated with awake bruxism susceptibility, clinical presentation, and patients' perceived stress level.

Methods

The study group included 104 patients with probable awake bruxism and 191 population controls. Patients underwent dental examination concerning the symptoms of bruxism and psychological testing. Genotyping was performed using HRMA and sequencing. Statistical analyses were conducted, and P values below 0.05 were considered statistically significant.

Results

We observed a positive correlation of mea

SUBMITTER: Maciejewska-Szaniec Z 

PROVIDER: S-EPMC8491599 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature