Myelin-associated proteins are potential diagnostic markers in patients with primary brain tumour.

ABSTRACT:

Introduction

Taking into account the possibility of myelin-associated proteins having a role in brain tumour development, the study aimed to evaluate the diagnostic usefulness of myelin-associated proteins (Nogo-A, MAG, OMgp) released into extracellular space in patients with brain tumours.

Patients and methods

Protein concentration in primary brain tumour (n = 49) and non-tumoural subjects (n = 24) was measured in cerebrospinal fluid (CSF) and serum by means of ELISA. Immunohistochemistry for IDH1-R132H was done on 5-μm thick formalin-fixed, paraffin-embedded tumour sections with the use of an antibody specific for the mutant IDH1-R132H protein.

Results

The receiver operator characteristic curve analysis showed that CSF Nogo-A and serum MAG were useful

SUBMITTER: Koper-Lenkiewicz OM 

PROVIDER: S-EPMC8491661 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature