Entrainment of Network Activity by Closed-Loop Microstimulation in Healthy Ambulatory Rats.

ABSTRACT: As our understanding of volitional motor function increases, it is clear that complex movements are the result of the interactions of multiple cortical regions rather than just the output properties of primary motor cortex. However, our understanding of the interactions among these regions is limited. In this study, we used the activity-dependent stimulation (ADS) technique to determine the short/long-term effects on network activity and neuroplasticity of intracortical connections. ADS uses the intrinsic neural activity of one region to trigger stimulations in a separate region of the brain and can manipulate neuronal connectivity in vivo. Our aim was to compare single-unit neuronal activity within premotor cortex (rostral forelimb area, [RFA] in rats) in response to ADS (triggered from R

SUBMITTER: Averna A 

PROVIDER: S-EPMC8491688 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature