Central Adiposity and Subsequent Risk of Breast Cancer by Menopause Status.

ABSTRACT:

Background

Increased body mass index (BMI) is associated with higher postmenopausal breast cancer risk and lower premenopausal breast cancer risk. Less is known about the central adiposity-breast cancer risk association, particularly for tumor subtypes.

Methods

We used prospective waist (WC) and hip circumference (HC) measures in the Nurses' Health Studies. We examined associations of WC, HC, and waist-to-hip ratio (WHR) with breast cancer independent of BMI, by menopausal status. Cox proportional hazards models estimated the hazard ratios (HRs) and 95% confidence intervals (CIs) adjusting for breast cancer risk factors, with and without BMI.

Results

Adjusting for BMI, WC and HC were not associated, and WHR was positively associated with premenopausal breast cancer ri

SUBMITTER: Houghton SC 

PROVIDER: S-EPMC8491796 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature