Salmonella Typhimurium impairs glycolysis-mediated acidification of phagosomes to evade macrophage defense.

ABSTRACT: Regulation of cellular metabolism is now recognized as a crucial mechanism for the activation of innate and adaptive immune cells upon diverse extracellular stimuli. Macrophages, for instance, increase glycolysis upon stimulation with pathogen-associated molecular patterns (PAMPs). Conceivably, pathogens also counteract these metabolic changes for their own survival in the host. Despite this dynamic interplay in host-pathogen interactions, the role of immunometabolism in the context of intracellular bacterial infections is still unclear. Here, employing unbiased metabolomic and transcriptomic approaches, we investigated the role of metabolic adaptations of macrophages upon Salmonella enterica serovar Typhimurium (S. Typhimurium) infections. Importantly, our results suggest that S. Typhimur

SUBMITTER: Gutierrez S 

PROVIDER: S-EPMC8491875 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature