Reduced myelin in patients with isolated hippocampal sclerosis as assessed by SyMRI.

ABSTRACT:

Purpose

Synthetic MRI (SyMRI) enables to quantify brain tissue and morphometry. We aimed to investigate the WM and myelin alterations in patients with unilateral hippocampal sclerosis (HS) with SyMRI.

Methods

Adult patients with isolated unilateral HS and age-matched control subjects (CSs) were included in this study. The SyMRI sequence QRAPMASTER in the coronal plane perpendicular to the hippocampi was obtained from the whole brain. Automatic segmentation of the whole brain was processed by SyMRI Diagnostic software (Version 11.2). Two neuroradiologists also performed quantitative analyses independently from symmetrical 14 ROIs placed in temporal and extratemporal WM, hippocampi, and amygdalae in both hemispheres.

Results

Sixteen patients (F/M = 6/10, mean age = 32.5

SUBMITTER: Parlak S 

PROVIDER: S-EPMC8492040 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature