Gut Resistome of Preschool Children After Prolonged Mass Azithromycin Distribution: A Cluster-randomized Trial.

ABSTRACT: We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.

Clinical trials registration

NCT02047981.

SUBMITTER: Arzika AM 

PROVIDER: S-EPMC8492121 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature