Dynamics and Dispersal of Local Human Immunodeficiency Virus Epidemics Within San Diego and Across the San Diego-Tijuana Border.

ABSTRACT:

Background

Evolutionary analyses of well-annotated human immunodeficiency virus (HIV) sequence data can provide insights into viral transmission patterns and associated factors. Here, we explored the transmission dynamics of the HIV-1 subtype B epidemic across the San Diego (US) and Tijuana (Mexico) border region to identify factors that could help guide public health policy.

Methods

HIV pol sequences were collected from people with HIV in San Diego County and Tijuana between 1996-2018. A multistep phylogenetic approach was used to characterize the dynamics of spread. The contributions of geospatial factors and HIV risk group to the local dynamics were evaluated.

Results

Phylogeographic analyses of the 2034 sequences revealed an important contribution of local transmi

SUBMITTER: Vrancken B 

PROVIDER: S-EPMC8492140 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature