Metabolic Response in Patients With Post-treatment Lyme Disease Symptoms/Syndrome.

ABSTRACT:

Background

Post-treatment Lyme disease symptoms/syndrome (PTLDS) occurs in approximately 10% of patients with Lyme disease following antibiotic treatment. Biomarkers or specific clinical symptoms to identify patients with PTLDS do not currently exist and the PTLDS classification is based on the report of persistent, subjective symptoms for ≥6 months following antibiotic treatment for Lyme disease.

Methods

Untargeted liquid chromatography-mass spectrometry metabolomics was used to determine longitudinal metabolic responses and biosignatures in PTLDS and clinically cured non-PTLDS Lyme patients. Evaluation of biosignatures included (1) defining altered classes of metabolites, (2) elastic net regularization to define metabolites that most strongly defined PTLDS and non-PTLDS pa

SUBMITTER: Fitzgerald BL 

PROVIDER: S-EPMC8492154 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature