Exposure to Diverse Plasmodium falciparum Genotypes Shapes the Risk of Symptomatic Malaria in Incident and Persistent Infections: A Longitudinal Molecular Epidemiologic Study in Kenya.

ABSTRACT:

Background

Repeated exposure to malaria infections could protect against symptomatic progression as people develop adaptive immunity to infections acquired over time.

Methods

We investigated how new, recurrent, and persistent Plasmodium falciparum infections were associated with the odds of developing symptomatic compared with asymptomatic malaria. Using a 14-month longitudinal cohort in Western Kenya, we used amplicon deep sequencing of 2 polymorphic genes (pfama1 and pfcsp) to assess overlap of parasite genotypes (represented by haplotypes) acquired within an individual's successive infections. We hypothesized infections with novel haplotypes would increase the odds of symptomatic malaria.

Results

After excluding initial infections, we observed 534 asymptomatic and

SUBMITTER: Sumner KM 

PROVIDER: S-EPMC8492207 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature