Prenatal Diethylstilbestrol Exposure and Cancer Risk in Males.

ABSTRACT:

Background

The influence of prenatal diethylstilbestrol (DES) exposure on cancer incidence among middle-aged men has not been well-characterized. We investigated whether exposure to DES before birth impacts overall cancer risk, and risk of site-specific cancers.

Methods

Men (mean age in 2016 = 62.0 years) who were or were not prenatally DES exposed were identified between 1953 and 1994 and followed for cancer primarily via questionnaire approximately every 5 years between 1994 and 2016. The overall and site-specific cancer rates of the two groups were compared using Poisson regression and proportional hazards modeling with adjustment for age.

Results

DES exposure was not associated with either overall cancer [hazard ratio (HR), 0.94; 95% confidence interval (CI), 0.77

SUBMITTER: Strohsnitter WC 

PROVIDER: S-EPMC8492497 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature