Associations of Subtype and Isomeric Plasma Carotenoids with Prostate Cancer Risk in Low-Income African and European Americans.

ABSTRACT:

Background

Various carotenoids in circulation, including isomers, may have different influences on cancer risk.

Methods

We conducted a nested case-control study including 343 incident prostate cancer cases and 640 controls individually matched on age, race, study site, and time of blood collection. Carotenoids investigated were carotene, cryptoxanthin, lycopene, dihydrolycopene, lutein, anhydrolutein, and zeaxanthin, including α versus β configurations and cis versus trans isomers. General linear model and conditional logistic regression were applied to evaluate associations for prostate cancer risk, with adjustment for potential confounders. We conducted additional analyses with further stratification by race, multivitamin use, and smoking status.

Results</

SUBMITTER: Lee SA 

PROVIDER: S-EPMC8492498 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature