Oral Antibiotics and Risk of New Colorectal Adenomas During Surveillance Follow-up.

ABSTRACT:

Background

Antibiotics may increase colorectal neoplasia risk by modifying the gut microbiome. It is unknown whether use is associated with the risk of new colorectal adenomas among individuals with prior adenomas.

Methods

We performed a secondary analysis of four randomized clinical trials for the chemoprevention of colorectal adenomas. Participants self-reported all currently used prescription drugs shortly after an initial colorectal adenoma diagnosis and two or three times a year thereafter over 3 to 5 years of follow-up. We estimated adjusted risk ratios (RR) with 95% confidence intervals (CI) for incident adenomas, analyzing the four trials together.

Results

Cumulatively, the four trials enrolled 5,174 participants (3,491 men and 1,683 women), of whom 4,769 (92%

SUBMITTER: Passarelli MN 

PROVIDER: S-EPMC8492500 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature