Radium-223-Induced Bystander Effects Cause DNA Damage and Apoptosis in Disseminated Tumor Cells in Bone Marrow.

ABSTRACT: Radiation-induced bystander effects have been implicated in contributing to the growth delay of disseminated tumor cells (DTC) caused by ²²³RaCl₂, an alpha particle-emitting radiopharmaceutical. To understand how ²²³RaCl₂ affects the growth, we have quantified biological changes caused by direct effects of radiation and bystander effects caused by the emitted radiations on DTC and osteocytes. Characterizing these effects contribute to understanding the efficacy of alpha particle-emitting radiopharmaceuticals and guide expansion of their use clinically. MDA-MB-231 or MCF-7 human breast cancer cells were inoculated intratibially into nude mice that were previously injected intravenously with 50 or 600 kBq/kg ²²³RaCl₂. At 1-day

SUBMITTER: Canter BS 

PROVIDER: S-EPMC8492514 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature