RosettaCM for antibodies with very long HCDR3s and low template availability.

ABSTRACT: Antibody-antigen co-crystal structures are a valuable resource for the fundamental understanding of antibody-mediated immunity. Determination of structures with antibodies in complex with their antigens, however, is a laborious task without guarantee of success. Therefore, homology modeling of antibodies and docking to their respective antigens has become a very important technique to drive antibody and vaccine design. The quality of the antibody modeling process is critical for the success of these endeavors. Here, we compare different computational protocols for predicting antibody structure from sequence in the biomolecular modeling software Rosetta-all of which use multiple existing antibody structures to guide modeling. Specifically, we compare protocols developed solely to predict an

SUBMITTER: Kodali P 

PROVIDER: S-EPMC8492515 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature