Self-Renewing Islet TCF1⁺ CD8 T Cells Undergo IL-27-Controlled Differentiation to Become TCF1^- Terminal Effectors during the Progression of Type 1 Diabetes.

ABSTRACT: In type 1 diabetes (T1D) autoreactive CD8 T cells infiltrate pancreatic islets and destroy insulin-producing β cells. Progression to T1D onset is a chronic process, which suggests that the effector activity of β-cell autoreactive CD8 T cells needs to be maintained throughout the course of disease development. The mechanism that sustains diabetogenic CD8 T cell effectors during the course of T1D progression has not been completely defined. Here we used single-cell RNA sequencing to gain further insight into the phenotypic complexity of islet-infiltrating CD8 T cells in NOD mice. We identified two functionally distinct subsets of activated CD8 T cells, CD44^highTCF1⁺CXCR6^- and CD44^highTCF1^-CXCR6⁺, in islets of prediabetic NOD m

SUBMITTER: Ciecko AE 

PROVIDER: S-EPMC8492517 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature