Lifetime Ambient UV Radiation Exposure and Risk of Basal Cell Carcinoma by Anatomic Site in a Nationwide U.S. Cohort, 1983-2005.

ABSTRACT:

Background

Cutaneous basal cell carcinoma (BCC) has long been associated with UV radiation (UVR) exposure, but data are limited on risks by anatomic site.

Methods

We followed 63,912 cancer-free White U.S. radiologic technologists from cohort entry (1983-1989/1994-1998) to exit (date first BCC via 2003-2005 questionnaire). We estimated associations between cumulative ambient UVR and relative/absolute risks of self-reported BCC by anatomic location via Poisson models.

Results

For incident first primary BCC in 2,124 subjects (mean follow-up, 16.9 years) log[excess relative risks] (ERR) of BCC per unit cumulative ambient UVR = 1.27/MJ cm^-2 [95% confidence interval (CI): 0.86-1.68; P _trend < 0.001] did not vary by anatomic site (P = 0.15

SUBMITTER: Little MP 

PROVIDER: S-EPMC8492548 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature