Pre-diagnosis neutrophil-to-lymphocyte ratio and mortality in individuals who develop lung cancer.

ABSTRACT:

Purpose

The neutrophil-to-lymphocyte ratio (NLR) is a marker of systemic inflammation that has been reported to be associated with survival after chronic disease diagnoses, including lung cancer. We hypothesized that the inflammatory profile reflected by pre-diagnosis NLR, rather than the well-studied pre-treatment NLR at diagnosis, may be associated with increased mortality after lung cancer is diagnosed in high-risk heavy smokers.

Methods

We examined associations between pre-diagnosis methylation-derived NLR (mdNLR) and lung cancer-specific and all-cause mortality in 279 non-small lung cancer (NSCLC) and 81 small cell lung cancer (SCLC) cases from the β-Carotene and Retinol Efficacy Trial (CARET). Cox proportional hazards models were adjusted for age, sex, smoking status,

SUBMITTER: Grieshober L 

PROVIDER: S-EPMC8492578 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature