Physical activity in relation to circulating hormone concentrations in 117,100 men in UK Biobank.

ABSTRACT:

Purpose

Physical activity may reduce the risk of some types of cancer in men. Biological mechanisms may involve changes in hormone concentrations; however, this relationship is not well established. Therefore, we aimed to investigate the associations of physical activity with circulating insulin-like growth factor-I (IGF-I), sex hormone-binding globulin (SHBG, which modifies sex hormone activity), and total and free testosterone concentrations, and the extent these associations might be mediated by body mass index (BMI).

Methods

Circulating concentrations of these hormones and anthropometric measurements and self-reported physical activity data were available for 117,100 healthy male UK Biobank participants at recruitment. Objectively measured accelerometer physical activity

SUBMITTER: Watts EL 

PROVIDER: S-EPMC8492588 | biostudies-literature | 2021 Nov

REPOSITORIES: biostudies-literature