Metformin to decrease COVID-19 severity and mortality: Molecular mechanisms and therapeutic potential.

ABSTRACT: The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has become a serious challenge for medicine and science. Analysis of the molecular mechanisms associated with the clinical manifestations and severity of COVID-19 has identified several key points of immune dysregulation observed in SARS-CoV-2 infection. For diabetic patients, factors including higher binding affinity and virus penetration, decreased virus clearance and decreased T cell function, increased susceptibility to hyperinflammation, and cytokine storm may make these patients susceptible to a more severe course of COVID-19 disease. Metabolic changes induced by diabetes, especially hyperglycemia, can directly affect the immunometabolism of lymphocytes in part by affecting the activity of the mTOR protein kinase signaling pa

SUBMITTER: Kamyshnyi O 

PROVIDER: S-EPMC8492612 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature