Ferroptosis in liver disease: new insights into disease mechanisms.

ABSTRACT: Characterized by excessive iron accumulation and lipid peroxidation, ferroptosis is a novel form of iron-dependent cell death, which is morphologically, genetically, and biochemically distinct from other well-known cell death. In recent years, ferroptosis has been quickly gaining attention in the field of liver diseases, as the liver is predisposed to oxidative injury and generally, excessive iron accumulation is a primary characteristic of most major liver diseases. In the current review, we first delineate three cellular defense mechanisms against ferroptosis (GPx4 in the mitochondria and cytosol, FSP1 on plasma membrane, and DHODH in mitochondria), along with four canonical modulators of ferroptosis (system Xc^-, nuclear factor erythroid 2-related factor 2, p53, and GTP cycloh

SUBMITTER: Wu J 

PROVIDER: S-EPMC8492622 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature