Immunoinformatics design of a novel epitope-based vaccine candidate against dengue virus.

ABSTRACT: Dengue poses a global health threat, which will persist without therapeutic intervention. Immunity induced by exposure to one serotype does not confer long-term protection against secondary infection with other serotypes and is potentially capable of enhancing this infection. Although vaccination is believed to induce durable and protective responses against all the dengue virus (DENV) serotypes in order to reduce the burden posed by this virus, the development of a safe and efficacious vaccine remains a challenge. Immunoinformatics and computational vaccinology have been utilized in studies of infectious diseases to provide insight into the host-pathogen interactions thus justifying their use in vaccine development. Since vaccination is the best bet to reduce the burden posed by DENV, thi

SUBMITTER: Fadaka AO 

PROVIDER: S-EPMC8492693 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature