Ontology highlight
ABSTRACT:
SUBMITTER: Dong XL
PROVIDER: S-EPMC8492710 | biostudies-literature | 2021 Oct
REPOSITORIES: biostudies-literature
Dong Xiao-Liu XL Wang Yan-Hui YH Xu Jing J Zhang Nan N
Scientific reports 20211005 1
Rolipram specifically inhibits phosphodiesterase (PDE) 4, thereby preventing inactivation of the intracellular second messenger cyclic adenosine monophosphate (cAMP). Rolipram has been shown to play a neuroprotective role in some central nervous system (CNS) diseases. However, the role of PDE4 and the potential protective effect of rolipram on the pathophysiological process of intracerebral haemorrhage (ICH) are still not entirely clear. In this study, a mouse model of ICH was established by the ...[more]