Dimension-reduction simplifies the analysis of signal crosstalk in a bacterial quorum sensing pathway.

ABSTRACT: Many pheromone sensing bacteria produce and detect more than one chemically distinct signal, or autoinducer. The pathways that detect these signals are typically noisy and interlocked through crosstalk and feedback. As a result, the sensing response of individual cells is described by statistical distributions that change under different combinations of signal inputs. Here we examine how signal crosstalk reshapes this response. We measure how combinations of two homoserine lactone (HSL) input signals alter the statistical distributions of individual cell responses in the AinS/R- and LuxI/R-controlled branches of the Vibrio fischeri bioluminescence pathway. We find that, while the distributions of pathway activation in individual cells vary in complex fashion with environmental conditions,

SUBMITTER: Miller T 

PROVIDER: S-EPMC8492804 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature