Serotonin 5-HT_2A receptor activity mediates adipocyte differentiation through control of adipogenic gene expression.

ABSTRACT: Serotonin 5-HT₂ receptors are expressed in many tissues and play important roles in biological processes. Although the 5-HT_2A receptor is primarily known for its role in central nervous system, it is also expressed in peripheral tissues. We have found that 5-HT_2A receptor antagonists inhibit human subcutaneous primary adipocyte differentiation. We also show that siRNA knockdown of the 5-HT_2A receptor blocks differentiation. Using gene expression analysis in combination with receptor antagonists we found that activity of 5-HT_2A receptors is necessary very early in the differentiation process to mediate expression of adipogenic genes, including peroxisome proliferator-activated receptor gamma (ppar-γ), adipocyte protein 2 (aP2), adiponec

SUBMITTER: Yu B 

PROVIDER: S-EPMC8492876 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature