Methylprednisolone in Pediatric Cardiac Surgery: Is There Enough Evidence?

ABSTRACT: Corticosteroids have been used to decrease the inflammatory response to cardiac surgery and cardiopulmonary bypass in children for decades. Sparse information is present concerning the pharmacokinetics and pharmacodynamics of corticosteroids in the context of pediatric cardiac surgery. There is large interindividual variability in plasma concentrations, with indications for a larger volume of distribution in neonates compared to other age groups. There is ample evidence that perioperative use of MP leads to a decrease in pro-inflammatory mediators and an increase in anti-inflammatory mediators, with no difference in effect between doses of 2 and 30 mg/kg. No differences in inflammatory mediators have been shown between different times of administration relative to the start of surgery in v

SUBMITTER: van Saet A 

PROVIDER: S-EPMC8492975 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature