Genotype Distribution Change After Human Papillomavirus Vaccination in Two Autonomous Communities in Spain.

ABSTRACT:

Context

It has been more than 10 years since the human papillomavirus (HPV) vaccination program was initiated in most advanced countries. Thus, it seems necessary to change the uterine cervical cancer screening strategy. Molecular-based tests are considered essential in this scenario.

Objective

We aimed to review the distribution of the HPV genotypes after the introduction of the vaccination program with Cervarix® and Gardasil 4® in two autonomous communities in Spain, looking for possible changes in distribution and the occurrence of a herd effect.

Design

A cross-sectional study was performed in 45,362 samples that were processed in the Cantabria and Aragon communities during the period from 2002 to 2016. We compared the genotype distribution before and after the vac

SUBMITTER: Freire-Salinas J 

PROVIDER: S-EPMC8493034 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature