A Mycobacterium tuberculosis Specific IgG3 Signature of Recurrent Tuberculosis.

ABSTRACT: South Africa has the highest prevalence of HIV and tuberculosis (TB) co-infection globally. Recurrent TB, caused by relapse or reinfection, makes up the majority of TB cases in South Africa, and HIV infected individuals have a greater likelihood of developing recurrent TB. Given that TB remains a leading cause of death for HIV infected individuals, and correlates of TB recurrence protection/risk have yet to be defined, here we sought to understand the antibody associated mechanisms of recurrent TB by investigating the humoral response in a longitudinal cohort of HIV co-infected individuals previously treated for TB with and without recurrent disease during follow-up, in order to identify antibody correlates of protection between individuals who do not have recurrent TB and individuals who

SUBMITTER: Fischinger S 

PROVIDER: S-EPMC8493041 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature