Frozen Embryo Transfer in Mildly Stimulated Cycle With Letrozole Compared to Natural Cycle in Ovulatory Women: A Large Retrospective Study.

ABSTRACT:

Objective

To evaluate the clinical effect of mild stimulation with letrozole on pregnancy outcomes in ovulatory women undergoing frozen embryo transfer (FET) compared to natural cycle.

Design

Retrospective observational study.

Setting

Tertiary care academic medical center.

Population

A total of 6,874 infertile women with regular menstrual cycles (21-35 days) met the criteria for this study in the period from 2013 to 2020.

Methods

All patients who were prepared for and underwent FET were divided into two groups: a modified natural cycle (NC) group (n=3,958) and a letrozole cycle group (n=2,916).

Main outcome measures

The primary outcome of the study was clinical pregnancy rate. Secondary outcome measures were endometrial thickness, rates of implant

SUBMITTER: Li D 

PROVIDER: S-EPMC8493067 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature