Comparison of the Ocular Microbiomes of Dry Eye Patients With and Without Autoimmune Disease.

ABSTRACT:

Purpose

The pathogenesis of dry eye concomitant with autoimmune disease is different from that of dry eye without autoimmune disease. The aim of this study was to explore differences in the microbiota diversity and composition in dry eye with and without autoimmune disease.

Methods

Swab samples from the inferior fornix of the conjunctival sac were obtained from dry eye patients without autoimmune disease (n = 49, dry eye group) and from those with autoimmune disease (n = 38, immdry eye group). Isolated bacterial DNAs from swabs were analyzed with 16S rRNA amplicon sequencing.

Results

Analysis of the alpha diversity revealed no significant differences between subjects in the dry eye and immdry eye groups. Those in the immdry eye group had a distinct micro

SUBMITTER: Qi Y 

PROVIDER: S-EPMC8493086 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature