Regulation of Long Non-coding RNA KCNQ1OT1 Network in Colorectal Cancer Immunity.

ABSTRACT: Over the past few decades, researchers have become aware of the importance of non-coding RNA, which makes up the vast majority of the transcriptome. Long non-coding RNAs (lncRNAs) in turn constitute the largest fraction of non-coding transcripts. Increasing evidence has been found for the crucial roles of lncRNAs in both tissue homeostasis and development, and for their functional contributions to and regulation of the development and progression of various human diseases such as cancers. However, so far, only few findings with regards to functional lncRNAs in cancers have been translated into clinical applications. Based on multiple factors such as binding affinity of miRNAs to their lncRNA sponges, we analyzed the competitive endogenous RNA (ceRNA) network for the colorectal cancer RNA-s

SUBMITTER: Liu J 

PROVIDER: S-EPMC8493092 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature