PD-L1⁺NEUT, Foxp3⁺Treg, and NLR as New Prognostic Marker with Low Survival Benefits Value in Hepatocellular Carcinoma.

ABSTRACT: Background: This presented study was aimed to evaluate the diagnostic and prognostic value of PD-L1⁺Neutrophils (PD-L1⁺NEUT) and neutrophil to lymphocyte ratio (NLR) based on our previous experience of Foxp3⁺Treg in transplantation. Methods: the NLR cutoff value of 1.79 was used to include 136 cases from the 204 patients with hepatocellular carcinoma (HCC) confirmed by clinical pathology, which were divided into highly-moderately and poorly differentiated HCC groups. The expressions of PD-L1⁺NEUT and Foxp3⁺Treg in peripheral blood and cancer tissue were detected with flow cytometry, meanwhile, PD-L1 and Foxp3 expressed in carcinoma and para-carcinoma tissues were marked by immunohistochemistry. Survival rates, including o

SUBMITTER: Zhou L 

PROVIDER: S-EPMC8493317 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature