Fibroblast Growth Factor 21 Ameliorates Na_V1.5 and Kir2.1 Channel Dysregulation in Human AC16 Cardiomyocytes.

ABSTRACT: Infarcted myocardium is predisposed to cause lethal ventricular arrhythmias that remain the main cause of death in patients suffering myocardial ischemia. Liver-derived fibroblast growth factor 21 (FGF21) is an endocrine regulator, which exerts metabolic actions by favoring glucose and lipids metabolism. Emerging evidence has shown a beneficial effect of FGF21 on cardiovascular diseases, but the role of FGF21 on ventricular arrhythmias following myocardial infarction (MI) in humans has never been addressed. This study was conducted to investigate the pharmacological effects of FGF21 on cardiomyocytes after MI in humans. Patients with arrhythmia in acute MI and healthy volunteers were enrolled in this study. Serum samples were collected from these subjects on day 1 and days 7-10 after the o

SUBMITTER: Li J 

PROVIDER: S-EPMC8493335 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature