Neurocognitive functioning in symptomatic adults with sickle cell disease: A description and comparison with unaffected siblings.

ABSTRACT: Children and adults with sickle cell disease (SCD) are at risk for neuropsychological deficits; however, the neurocognitive functioning of adults with SCD and related comorbidities has not been widely reported in the literature. We examined specific cognitive domains in symptomatic adults with SCD and compared them with their unaffected siblings. We also examined relationships between cognitive scores, patient-reported outcomes (PROs), and medical/laboratory values. Thirty patient-sibling pairs (M patient age = 32.5 years, M sibling age = 32.1 years) completed evaluations as part of a medical clinical trial (NCT00061568). All patient and sibling neurocognitive test scores were within normal limits. Patients scored significantly lower (M = 91.0 ± 11.3) than their siblin

SUBMITTER: Martin S 

PROVIDER: S-EPMC8493482 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature