Lipid Cubic Systems for Sustained and Controlled Delivery of Antihistamine Drugs.

ABSTRACT: Antihistamines are capable of blocking mediator responses in allergic reactions including allergic rhinitis and dermatological reactions. By incorporating various H₁ receptor antagonists into a lipid cubic phase network, these active ingredients can be delivered locally over an extended period of time owing to the mucoadhesive nature of the system. Local delivery can avoid inducing unwanted side effects, often observed after systematic delivery. Lipid-based antihistamine delivery systems are shown here to exhibit prolonged release capabilities. In vitro drug dissolution studies investigated the extent and release rate of two model first-generation and two model second-generation H₁ antagonist antihistamine drugs from two monoacyglycerol-derived lipid models. To optimi

SUBMITTER: Dully M 

PROVIDER: S-EPMC8493555 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature