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Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy.


ABSTRACT: The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, we noted multiple clonal clusters of identical intact or defective proviral sequences from distinct compartments and CD4 T-cell subpopulations, suggesting frequent interchanges between viral reservoir cells in blood and tissues.

SUBMITTER: Kuo HH 

PROVIDER: S-EPMC8493664 | biostudies-literature | 2020 Jul

REPOSITORIES: biostudies-literature

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Blood and Lymph Node Dissemination of Clonal Genome-Intact Human Immunodeficiency Virus 1 DNA Sequences During Suppressive Antiretroviral Therapy.

Kuo Hsiao-Hsuan HH   Banga Riddhima R   Lee Guinevere Q GQ   Gao Ce C   Cavassini Matthias M   Corpataux Jean-Marc JM   Blackmer Jane E JE   Zur Wiesch Schulze S   Yu Xu G XG   Pantaleo Giuseppe G   Perreau Matthieu M   Lichterfeld Mathias M  

The Journal of infectious diseases 20200701 4


The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, w  ...[more]

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