Ontology highlight
ABSTRACT:
SUBMITTER: Kuo HH
PROVIDER: S-EPMC8493664 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Kuo Hsiao-Hsuan HH Banga Riddhima R Lee Guinevere Q GQ Gao Ce C Cavassini Matthias M Corpataux Jean-Marc JM Blackmer Jane E JE Zur Wiesch Schulze S Yu Xu G XG Pantaleo Giuseppe G Perreau Matthieu M Lichterfeld Mathias M
The Journal of infectious diseases 20200701 4
The majority of cells with latent human immunodeficiency virus 1 infection are located in lymphoid tissues that are difficult to access. In the current study, we used single-genome near-full-length proviral sequencing to evaluate intact and defective proviruses in blood and lymph node CD4 T cells enriched for specific functional polarizations. We observed minor variations between the frequencies of proviral sequences within individual CD4 T-cell subsets and across tissue compartments. However, w ...[more]