BMI1 is associated with CS8F amyloid-β and rates of cognitive decline in Alzheimer's disease.

ABSTRACT:

Background

Accumulating evidence suggests that BMI1 confers protective effects against Alzheimer's disease (AD). However, the mechanism remains elusive. Based on recent pathophysiological evidence, we sought for the first time to identify genetic variants in BMI1 as associated with AD biomarkers, including amyloid-β.

Methods

We used genetic, longitudinal cognition, and cerebrospinal fluid (CSF) biomarker data from participants in the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort (N = 1565). First, we performed a gene-based association analysis of common single nucleotide polymorphisms (SNPs) (minor allele frequency (MAF) > 5%) located within ± 20 kb of the gene boundary of BMI1, an optimal width for including potential regulatory SNPs in the 5' and 3' untranslate

SUBMITTER: Kim JP 

PROVIDER: S-EPMC8493672 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature