Comparative metabolic profiling of posterior parietal cortex, amygdala, and hippocampus in conditioned fear memory.

ABSTRACT: Fear conditioning and retrieval are suitable models to investigate the biological basis of various mental disorders. Hippocampus and amygdala neurons consolidate conditioned stimulus (CS)-dependent fear memory. Posterior parietal cortex is considered important for the CS-dependent conditioning and retrieval of fear memory. Metabolomic screening among functionally related brain areas provides molecular signatures and biomarkers to improve the treatment of psychopathologies. Herein, we analyzed and compared changes of metabolites in the hippocampus, amygdala, and posterior parietal cortex under the fear retrieval condition. Metabolite profiles of posterior parietal cortex and amygdala were similarly changed after fear memory retrieval. While the retrieval of fear memory perturbed various met

SUBMITTER: Jeon Y 

PROVIDER: S-EPMC8493686 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature