Msx1 haploinsufficiency modifies the Pax9-deficient cardiovascular phenotype.

ABSTRACT:

Background

Successful embryogenesis relies on the coordinated interaction between genes and tissues. The transcription factors Pax9 and Msx1 genetically interact during mouse craniofacial morphogenesis, and mice deficient for either gene display abnormal tooth and palate development. Pax9 is expressed specifically in the pharyngeal endoderm at mid-embryogenesis, and mice deficient for Pax9 on a C57Bl/6 genetic background also have cardiovascular defects affecting the outflow tract and aortic arch arteries giving double-outlet right ventricle, absent common carotid arteries and interruption of the aortic arch.

Results

In this study we have investigated both the effect of a different genetic background and Msx1 haploinsufficiency on the presentation of the Pax9-deficient cardi

SUBMITTER: Khasawneh RR 

PROVIDER: S-EPMC8493722 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature