Fibrinogen activates focal adhesion kinase (FAK) promoting colorectal adenocarcinoma growth.

ABSTRACT:

Background

We previously showed that fibrinogen is a major determinant of the growth of a murine model of colorectal cancer (CRC).

Objective

Our aim was to define the mechanisms coupling fibrin(ogen) to CRC growth.

Results

CRC tumors transplanted into the dorsal subcutis of Fib^- mice were less proliferative and demonstrated increased senescence relative to those grown in Fib⁺ mice. RNA-seq analyses of Fib⁺ and Fib^- tumors revealed 213 differentially regulated genes. One gene highly upregulated in tumors from Fib^- mice was stratifin, encoding 14-3-3σ, a master regulator of proliferation/senescence. In a separate cohort, we observed significantly increased protein levels of 14-3-3σ and its upstream and downstream ta

SUBMITTER: Sharma BK 

PROVIDER: S-EPMC8493761 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature