Orthogonal binding and displacement of different guest types using a coordination cage host with cavity-based and surface-based binding sites.

ABSTRACT: The octanuclear Co(ii) cubic coordination cage system H (or HW if it bears external water-solubilising substituents) has two types of binding site for guests. These are (i) the partially-enclosed central cavity where neutral hydrophobic organic species can bind, and (ii) the six 'portals' in the centres of each of the faces of the cubic cage where anions bind via formation of a network of CH⋯X hydrogen bonds between the anion and CH units on the positively-charged cage surface, as demonstrated by a set of crystal structures. The near-orthogonality of these guest binding modes provides the basis for an unusual dual-probe fluorescence displacement assay in which either a cavity-bound fluorophore (4-methyl-7-amino-coumarin, MAC; λ _em = 440 nm), or

SUBMITTER: Ludden MD 

PROVIDER: S-EPMC8494021 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature