Visible light-mediated radical fluoromethylation via halogen atom transfer activation of fluoroiodomethane.

ABSTRACT: Incorporation of the fluoromethyl group can profoundly influence the physicochemical properties of organic molecules, offering a promising strategy for the discovery of novel pharmaceutical agents. Direct fluoromethylation of unfunctionalized C(sp²) centres can be achieved using fluoromethyl radicals, but current methods for their generation usually rely on the activation of non-commercial or expensive radical precursors via inefficient single electron transfer pathways, which limits their synthetic application. Here we report the development of a fluoromethylation strategy based on the generation of fluoromethyl radicals from commercially available fluoroiodomethane via halogen atom transfer. This mode of activation is orchestrated by visible light and tris(trimet

SUBMITTER: Deneny PJ 

PROVIDER: S-EPMC8494037 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature